Abstract
In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at micro-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry
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Alkenes / pharmacology
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Amines / chemistry*
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Amines / pharmacology*
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Amino Alcohols / chemistry
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Amino Alcohols / pharmacology
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Animals
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Guinea Pigs
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Hydrocarbons, Aromatic / chemistry
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Hydrocarbons, Aromatic / pharmacology
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Ligands
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Models, Molecular
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Protein Binding
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Rats
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Receptors, Opioid / metabolism
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Receptors, sigma / metabolism*
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Structure-Activity Relationship
Substances
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Alkenes
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Amines
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Amino Alcohols
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Hydrocarbons, Aromatic
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Ligands
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Receptors, Opioid
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Receptors, sigma